28-Sep-2021 | Market Research Store

The crucial enzyme of the innate immune system, APOBEC3A,is responsiblefor protecting cells from numerous types of viral infections. The enzymeinduces mutations that combat the viruses fromreplication. Moreover,the protein targets the tumor-causing cells by attacking their genomes, thereby combating cancer proliferation.

According to Rémi Buisson, who is an assistant professor at the University of California,APOBEC3A-induced DNA alterations are quite common in cancer patients. Indeed, the team discovered that in 80% of the cases, mutationswere induced in specific cancer types like bladder,lung, and breasttumors.

Sunwoo Oh, a graduate student at UCI, along with Elodie Bournique, a postdoctoral researcher in the university, investigated how APOBEC3A is upregulated by the chemotherapeutic drugs stimulating viral infection and genotoxic stress. Their findings revealthe comprehensive mechanism of activation of APOBEC3A expression with a particular innate immune response developed bya viral infection, which is a critical stage in the destruction of the infection-causing virus. This research also focused on several chemotherapeutic medicines that stimulate APOBEC3A, which eventually led to the induction of mutations that aggravate cancer development.

Rémi Buisson said thatthe study indicatesnumerous mechanisms through which cells regulate APOBEC3A expression in response to various types of stressors. By understanding the mechanism that explicates how cancer cells and viral infections regulate APOBEC3A expression, the researchers will be able to make significant progress toward the development of novel anti-tumor and anti-viral medicines.

Further research is necessary to discover more ways to prevent APOBEC3A-induced DNA mutations in the cancer genome by boosting disease progression, increasing therapy resistance, and enhancing tumor heterogeneity. In the case of viral infections, the upcoming step is to review if certain types of mutations have been previously discovered in viruses like SARS-CoV-2 (COVID-19), which wereparticularly caused due to APOBEC3A activity and undermine the viral replication mechanism inside the host cells.

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https://www.marketresearchstore.com/market-insights/global-viral-clearance-service-market-research-report-2020-772369